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Detection of Epstein-Barr Virus Sequences in Primary Brain Lymphoma Without Immunodeficiency Neurol 41:1152-1153, Bignon,Y.J.,et al, 1991 See this aricle in Pubmed Article Abstract We searched for Epstein-Barr virus(EBV)sequences by enzymatic DNA amplification in nine primary brain lymphomas from patients without immunodeficiency.We used seven nonlymphoma brain tumors as negative controls,and the Raji cell line as a positive control.We detected EBV DNA, using ithidium bromide-stained-agarose minigel electrophoresis and dot blot hybridization,in the positive control and in only one brain lymphoma tumor;we did not detect EBV DNA in the other tumors.The EBV-positive patient had a second B-cell monoclonal population in the peripheral blood without detectable EBV DNA,suggesting a direct role for EBV in the development of the brain lymphoma.

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(click to filter results - removes previous filter) Epstein-Barr virus lymphoma lymphoma involving CNS lymphoma,primary of CNS neoplasm,primary of CNS polymerase chain reaction viral infection viral infection,CNS

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